Analysis Tools
digestive/alimentary system
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• newborn homozygotes display abnormal persistence of ciliated cells in the esophageal epithelium
• however, budding from the foregut endoderm and tracheoesophageal separation occur normally
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• neonatal esophageal epithelium consists largely of a highly organized, columnar ciliated epithelium that appears to lack K14+ basal cells, unlike in wild-type mice where several layers of cells with few ciliated cells and many K14+ basal cells are observed
• mutant ciliated cells make contact with the basement membrane, unlike cells in wild-type mice
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respiratory system
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• neonatal tracheobronchial epithelium shows a significantly higher number of ciliated cells than in wild-type controls
• however, a trachea is formed suggesting that budding from the foregut endoderm and tracheoesophageal separation occur normally
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• neonatal tracheal epithelial lining consists of a well-organized, columnar ciliated epithelium that lacks basal cells, unlike in wild-type mice
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