Phenotypes for Atp1a4 MGI:4941051 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Atp1a4^tm1Itl/Atp1a4^tm1Itl
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a4^tm1Itl mutation (0 available); any Atp1a4 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:169420 )

N	• female mice are fertile • testes morphology is normal

teratozoospermia ( J:169420 )

kinked sperm flagellum ( J:169420 )

• between the mid- and principal piece

impaired sperm capacitation ( J:169420 )

• hyperactivation typical of sperm capacitation is reduced compared with wild-type sperm

male infertility ( J:169420 )

impaired fertilization ( J:169420 )

• sperm fail to fertilize oocytes in vitro unlike wild-type sperm

abnormal sperm physiology ( J:169420 )

• sperm lack sodium-potassium ATPase activity compared with wild-type cells

• sperm exhibit altered internal sodium concentration and membrane potential compared with wild-type sperm

asthenozoospermia ( J:169420 )

cellular

teratozoospermia ( J:169420 )

kinked sperm flagellum ( J:169420 )

• between the mid- and principal piece

asthenozoospermia ( J:169420 )

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