Phenotypes Associated with This Genotype

Genotype
MGI:4940865

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Pim1-E2F1)Rebr}/Gt(ROSA)26Sor⁺; Tmem163^{Tg(ACTB-cre)2Mrt}/0
• Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:83303 )

• marginally fewer than expected mice are present at 3 weeks

skeleton

abnormal skeleton morphology ( J:83303 )

abnormal long bone epiphyseal plate proliferative zone ( J:83303 )

• the area of columnar proliferating chondrocytes is larger than in wild-type mice

decreased width of hypertrophic chondrocyte zone ( J:83303 )

• prehypertrophic and hypertrophic zones are reduced in size compared to in wild-type mice

growth/size/body

decreased body size ( J:83303 )

postnatal growth retardation ( J:83303 )

• in 2 of 30 mice