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Phenotypes Associated with This Genotype
Genotype
MGI:4940639
Allelic
Composition		 Abcg1tm1Dgen/Abcg1tm1Dgen
Abcg4tm1Dgen/Abcg4+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg1tm1Dgen mutation (0 available); any Abcg1 mutation (45 available)
Abcg4tm1Dgen mutation (0 available); any Abcg4 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased cholesterol efflux ( J:141549 )
• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells
abnormal lipid homeostasis ( J:141549 )
• astrocytes exhibit decreased sterol synthesis compared with wild-type cells
• astrocyte desmosterol efflux is decreased compared to in wild-type cells
• astrocyte HDL-dependent desmosterol efflux is decreased compared to in wild-type cells
abnormal lipid level ( J:141549 )
• desmosterol levels are increased 2-fold in astrocytes compared to in wild-type cells

cellular
decreased cholesterol efflux ( J:141549 )
• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory