Phenotypes Associated with This Genotype

Genotype
MGI:4940071

• Allelic Composition: Tg(Thy1-MAPT*)30Schd/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:169074 )

• mice show reduced survival relative to wild-type, with almost 100% mortality observed by 18 months

behavior/neurological

behavior/neurological phenotype ( J:169074 )

N • in Y-maze tests, percentage of alternations observed is not significantly different from double transgenics, Mapt mutants or wild-type at 3-6 months of age; however, number of arm entries is significantly higher than wild-type or double mutants

N • spatial working memory is not impaired

impaired coordination ( J:169074 )

• mice show a progressive motor deficit, significant at 9 and 12 months compared to wild-type or Mapt mutants

abnormal posture ( J:111982 )

• by 7-8 months of age, mice display dystonic posture

hindlimb paralysis ( J:111982 )

• by 7-8 months of age, mice have paralyzed hindlimbs

nervous system

abnormal brain morphology ( J:169074 )

• GSK-3 kinase activation in the spinal cord is increased compared to wild-type

neurofibrillary tangles ( J:169074 )

• paired helical filaments (PHFs) in the insoluble tau fraction of neurofibrillary tangles show a low level of recruitment of endogenous murine tau; major component is transgenic human tau

• NFTs are composed mainly of bundles of straight filaments with occasional twisted filaments resembling PHFs observed in AD and other tauopathies

abnormal sciatic nerve morphology ( J:169074 )

• mice display axonal loss and reduction in cross-sectional area and axon density in the sciatic nerve compared to wild-type or Mapt mutants

abnormal spinal cord morphology ( J:169074 )

• mice develop numerous pericaryal rounded inclusions in the spinal cord; these are composed to abnormal filaments mixed with abundant neurofilaments