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Phenotypes Associated with This Genotype
Genotype
MGI:4939894
Allelic
Composition
Rassf5tm1Kina/Rassf5tm1Kina
Genetic
Background
B6.Cg-Rassf5tm1Kina
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• primary B cells exhibit accelearated S phase entry after stimulation
• primary T cells exhibit accelerated S phase entry after stimulation

respiratory system
• mutants develop lung adenocarcinomas after 1.5 years of age

liver/biliary system
• mutants develop hepatocellular carcinomas after 1.5 years of age

immune system
• total B and T cells are increased by about 50%
• CD138+B220+ plasma cells are increased in 10 month old female mutants
• total B and T cells are increased by about 50%
• CD44+CD62L- effector-memory T cells are increased in 10 month old female mutants
• lymphocyte hyperproliferation, with lymphocytes exhibiting enhanced S phase entry after stimulation
• primary B cells exhibit accelearated S phase entry after stimulation
• primary T cells exhibit accelerated S phase entry after stimulation
• aged mice exhibit a 2-fold increase in serum IgG compared to wild-type mice
• deposits of IgG and C3 in the kidney
• aged mice exhibit high titers of antibodies to dsDNA
• females exhibit evidence of glomerulonephritis by 10 months of age while males show similar phenotypes at a later age of 15-18 months

neoplasm
• mutants develop hepatocellular carcinomas after 1.5 years of age
• mutants develop B220+CD19+ diffuse large B cell lymphomas
• about 30% of mutants develop B cell lymphomas in peripheral lymph nodes and spleen at 1 year of age
• lymphomas are IgM+, IgD+, CD21+, CD23+, and mature B cell type; progressed lymphomas often lose these markers
• lymphomas are monoclonal or oligoclonal in origin
• B cell lymphomas are not related to severity of autoimmune phenotypes
• mutants develop lung adenocarcinomas after 1.5 years of age

hematopoietic system
• total B and T cells are increased by about 50%
• CD138+B220+ plasma cells are increased in 10 month old female mutants
• total B and T cells are increased by about 50%
• CD44+CD62L- effector-memory T cells are increased in 10 month old female mutants
• lymphocyte hyperproliferation, with lymphocytes exhibiting enhanced S phase entry after stimulation
• primary B cells exhibit accelearated S phase entry after stimulation
• primary T cells exhibit accelerated S phase entry after stimulation
• aged mice exhibit a 2-fold increase in serum IgG compared to wild-type mice
• deposits of IgG and C3 in the kidney

homeostasis/metabolism

renal/urinary system
• females exhibit evidence of glomerulonephritis by 10 months of age while males show similar phenotypes at a later age of 15-18 months


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory