Phenotypes Associated with This Genotype

Genotype
MGI:4939801

• Allelic Composition: Ifnar2^tm1Pjh/Ifnar2^tm1Pjh; Il6st^tm1Ern/Il6st^tm1Ern
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:168781 )

• mice fail to survive beyond 72 hours after treatment with an LPS dose that is sub-lethal to wild-type mice

immune system

increased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice

increased susceptibility to endotoxin shock ( J:168781 )

• mice fail to survive beyond 72 hours after treatment with an LPS dose that is sub-lethal to wild-type mice

• LPS-treated mice exhibit an increase in IL6 serum levels compared with similarly treated wild-type mice

homeostasis/metabolism

increased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:168781 )

• mice fail to survive beyond 72 hours after treatment with an LPS dose that is sub-lethal to wild-type mice