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Phenotypes Associated with This Genotype
Genotype
MGI:4939800
Allelic
Composition		 Il6sttm1Ern/Il6sttm1Ern
Tiraptm1.1Pjh/Tiraptm1.1Pjh
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6sttm1Ern mutation (17 available); any Il6st mutation (84 available)
Tiraptm1.1Pjh mutation (1 available); any Tirap mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating interleukin-6 level ( J:168781 )
• in LPS-treated mice compared with similarly treated Il6sttm1Ern homozygotes
decreased susceptibility to endotoxin shock ( J:168781 )
• LPS-treated mice exhibit increased survival and decreased serum IL6 compared with similarly treated Il6sttm1Ern homozygotes

homeostasis/metabolism
decreased circulating interleukin-6 level ( J:168781 )
• in LPS-treated mice compared with similarly treated Il6sttm1Ern homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory