Phenotypes Associated with This Genotype

Genotype
MGI:4939592

• Allelic Composition: Ccdc40^lnks/Ccdc40^lnks
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:168691 )

• most mice die prior to weaning of unknown causes

growth/size/body

heterotaxia ( J:168691 )

• in 39% of mice at E11.5 to E15.5

left-sided isomerism ( J:168691 )

• in 19% of mice at E11.5 to E15.5

left pulmonary isomerism ( J:168691 )

• in some mice

lung situs inversus ( J:168691 )

• in some mice

situs inversus ( J:168691 )

• in 8% of mice at E11.5 to E15.5

embryo

abnormal motile primary cilium morphology ( J:168691 )

• cilia are short compared to in wild-type mice

nervous system

hydrocephaly ( J:168691 )

renal/urinary system

renal/urinary system phenotype ( J:168691 )

N • mice do not develop kidney cysts

respiratory system

left pulmonary isomerism ( J:168691 )

• in some mice

lung situs inversus ( J:168691 )

• in some mice

cellular

abnormal motile primary cilium morphology ( J:168691 )

• cilia are short compared to in wild-type mice