Phenotypes Associated with This Genotype

Genotype
MGI:4938194

• Allelic Composition: Vegfa^tm2Gne/Vegfa⁺; Tg(SFTPC-rtTA)5Jaw/0; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

decreased pulmonary endothelial cell surface ( J:124125 )

• at E18.5, doxycycline-exposed mice exhibit a reduction in pulmonary endothelial cell development that is intermediate between those of wild-type controls and those carrying two Vegfa^tm2Gne alleles

abnormal pulmonary circulation ( J:124125 )

• newborn mice exposed to doxycycline from E6.5 display pale lungs, indicating reduced pulmonary circulation

abnormal lung development ( J:124125 )

• mice exposed to doxycycline from E6.5 display defective distal lung saccular development due to moderately reduced primary septation

abnormal lung saccule morphology ( J:124125 )

• at E18.5, doxycycline-exposed mice display dilated distal airspaces of a size that is intermediate between those of wild-type controls and those carrying two Vegfa^tm2Gne alleles

• the mean linear intercept, a reflection of airspace size and hence an indirect measure of septation incidence, is inversely related to the Vegfa gene dosage

pale lung ( J:124125 )

• newborn mice exposed to doxycycline from E6.5 display pale lungs

cardiovascular system

decreased pulmonary endothelial cell surface ( J:124125 )

• at E18.5, doxycycline-exposed mice exhibit a reduction in pulmonary endothelial cell development that is intermediate between those of wild-type controls and those carrying two Vegfa^tm2Gne alleles

abnormal pulmonary circulation ( J:124125 )

• newborn mice exposed to doxycycline from E6.5 display pale lungs, indicating reduced pulmonary circulation