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Phenotypes Associated with This Genotype
Genotype
MGI:4938180
Allelic
Composition		 \Mettm1Sst/\Mettm1Sst
\Tg(SFTPC-rtTA)5Jaw/0
\Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Sst mutation (1 available); any Met mutation (81 available)
Tg(SFTPC-rtTA)5Jaw mutation (5 available)
Tg(tetO-cre)1Jaw mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal lung development ( J:124125 )
• newborn mice exposed to doxycycline from E14.5 to birth display defective distal lung saccular development due to reduced primary septation
abnormal lung saccule morphology ( J:124125 )
• newborn mice exposed to doxycycline from E14.5 to birth display dilated distal airspaces with only few primary septae, unlike wild-type controls where extensive numbers of saccules are observed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory