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Phenotypes Associated with This Genotype
Genotype
MGI:4936868
Allelic
Composition
Adh7tm1Gdu/Adh7tm1Gdu
Genetic
Background
B6.129(Cg)-Adh7tm1Gdu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh7tm1Gdu mutation (1 available); any Adh7 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mutants exhibit normal spontaneous rearing, motility and locomotion
• administration of D-amphetamine significantly increases the motility and locomotion of 12-17 month old male mutants compared to wild-type mice
• administration of apomorphine results in a higher response in horizontal movement in 12-17 month old mutants than in wild-type mice
• administration of D-amphetamine significantly increases the motility and locomotion of 12-17 month old male mutants compared to wild-type mice
• administration of apomorphine results in a higher response in horizontal movement in 12-17 month old mutants than in wild-type mice

growth/size/body
• males exhibit a lower weight than controls at 12-17 months of age

nervous system
• levels of dopamine and dopamine dihydroxyphenylacetic acid (DOPAC), a monoamine metabolite, are increased in the substantia nigra
• significantly increased levels of the monoamine metabolite, DOPAC are observed in the olfactory bulb, however levels of dopamine are normal

taste/olfaction
• 18-20 month old mutants exhibit impaired olfaction, with mice showing longer times to find an odor target than wild-type mice

homeostasis/metabolism
• levels of dopamine and dopamine dihydroxyphenylacetic acid (DOPAC), a monoamine metabolite, are increased in the substantia nigra

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:PS168600
J:167234


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory