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Phenotypes Associated with This Genotype
Genotype
MGI:4936857
Allelic
Composition
Pkhd1tm1Gwu/Pkhd1tm1Gwu
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkhd1tm1Gwu mutation (0 available); any Pkhd1 mutation (110 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• kidneys exhibit increased apoptosis as indicated with increased caspase-3 and TUNEL staining; considerable apoptotic debris is seen in the lumen of renal tubules
• 6-week and 6-month old mice exhibit less cell proliferation in the kidneys than controls as indicated by fewer positive Phospho-Histone H3 staining spots and reduced PCNA staining

cellular
• kidneys exhibit increased apoptosis as indicated with increased caspase-3 and TUNEL staining; considerable apoptotic debris is seen in the lumen of renal tubules
• 6-week and 6-month old mice exhibit less cell proliferation in the kidneys than controls as indicated by fewer positive Phospho-Histone H3 staining spots and reduced PCNA staining

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:167782


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory