About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4936857
Allelic
Composition
Pkhd1tm1Gwu/Pkhd1tm1Gwu
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkhd1tm1Gwu mutation (0 available); any Pkhd1 mutation (137 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• kidneys exhibit increased apoptosis as indicated with increased caspase-3 and TUNEL staining; considerable apoptotic debris is seen in the lumen of renal tubules
• 6-week and 6-month old mice exhibit less cell proliferation in the kidneys than controls as indicated by fewer positive Phospho-Histone H3 staining spots and reduced PCNA staining

cellular
• kidneys exhibit increased apoptosis as indicated with increased caspase-3 and TUNEL staining; considerable apoptotic debris is seen in the lumen of renal tubules
• 6-week and 6-month old mice exhibit less cell proliferation in the kidneys than controls as indicated by fewer positive Phospho-Histone H3 staining spots and reduced PCNA staining

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive polycystic kidney disease DOID:0110861 OMIM:263200
J:167782


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/13/2017
MGI 6.10
The Jackson Laboratory