Mouse Genome Informatics
hm
    Pkhd1tm1Gwu/Pkhd1tm1Gwu
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
renal/urinary system
• kidneys exhibit increased apoptosis as indicated with increased caspase-3 and TUNEL staining; considerable apoptotic debris is seen in the lumen of renal tubules
• 6-week and 6-month old mice exhibit less cell proliferation in the kidneys than controls as indicated by fewer positive Phospho-Histone H3 staining spots and reduced PCNA staining

cellular
• kidneys exhibit increased apoptosis as indicated with increased caspase-3 and TUNEL staining; considerable apoptotic debris is seen in the lumen of renal tubules
• 6-week and 6-month old mice exhibit less cell proliferation in the kidneys than controls as indicated by fewer positive Phospho-Histone H3 staining spots and reduced PCNA staining

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:167782