Phenotypes Associated with This Genotype

Genotype
MGI:4936857

• Allelic Composition: Pkhd1^tm1Gwu/Pkhd1^tm1Gwu
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased renal tubule apoptosis ( J:167782 )

• kidneys exhibit increased apoptosis as indicated with increased caspase-3 and TUNEL staining; considerable apoptotic debris is seen in the lumen of renal tubules

decreased kidney cell proliferation ( J:167782 )

• 6-week and 6-month old mice exhibit less cell proliferation in the kidneys than controls as indicated by fewer positive Phospho-Histone H3 staining spots and reduced PCNA staining

cellular

increased renal tubule apoptosis ( J:167782 )

• kidneys exhibit increased apoptosis as indicated with increased caspase-3 and TUNEL staining; considerable apoptotic debris is seen in the lumen of renal tubules

decreased kidney cell proliferation ( J:167782 )

• 6-week and 6-month old mice exhibit less cell proliferation in the kidneys than controls as indicated by fewer positive Phospho-Histone H3 staining spots and reduced PCNA staining

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive polycystic kidney disease		DOID:0110861	OMIM:263200	J:167782