Analysis Tools
respiratory system
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• at E11.5, mutant embryos display esophageal atresia with tracheoesophageal fistula, in which the esophagus is missing and the trachea is directly connected to the stomach
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• at E16.5, the left and right lobes are fused, resulting in a single-lobed lung
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• at E16.5, mutant lungs fail to separate into right and left lobes and are thus composed of a single lobe, whereas wild-type and homozygous Gli2tm1Alj mutant lungs have five and two lobes, respectively
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• mutant lung buds do not form until E10.0, unlike in wild-type and homozygous Gli2tm1Alj mutant embryos where a pair of lung buds can be seen at E9.5
• at E11.5, an ectopic lung bud is found between the right and left lung buds
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• at E16.5, mutant lungs are more hypoplastic than those of wild-type or homozygous Gli2tm1Alj mutant embryos
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• at E16.5, the tracheal cartilaginous rings are more severely malformed than those in Gli2tm1Alj mutant embryos
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• at E16.5, tracheal stenosis is more severe than that in Gli2tm1Alj mutant lungs
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digestive/alimentary system
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• at E11.5, mutant embryos display esophageal atresia with tracheoesophageal fistula
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• at E11.5, mutant embryos display esophageal atresia with tracheoesophageal fistula, in which the esophagus is missing and the trachea is directly connected to the stomach
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skeleton
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• at E16.5, the tracheal cartilaginous rings are more severely malformed than those in Gli2tm1Alj mutant embryos
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