Phenotypes Associated with This Genotype

Genotype
MGI:4889195

• Allelic Composition: Invs^inv/Invs^inv
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

right aortic arch ( J:104135 )

• at E18.5, most homozygotes (11 of 16) display a right-sided aortic arch

double aortic arch ( J:104135 )

• at E18.5, 1 of 16 homozygotes displays a double aortic arch

aorta hypoplasia ( J:104135 )

• at E18.5, 1 of 16 homozygotes displays a right-sided aortic arch with an underdeveloped aorta

dextrocardia ( J:104135 )

• at E18.5, the heart is malpositioned to the right

respiratory system

left pulmonary isomerism ( J:104135 )

• at E18.5, 1 of 16 homozygotes displays left pulmonary isomerism

lung situs inversus ( J:104135 )

• at E18.5, >50% of homozygotes display a reversal of lung laterality resulting in a single-lobed right lung and a four-lobed left lung

right pulmonary isomerism ( J:104135 )

• at E18.5, 3 of 16 homozygotes display right pulmonary isomerism

digestive/alimentary system

right-sided stomach ( J:104135 )

• at E18.5, 10 of 16 homozygotes display a right-sided stomach

• the sidedness of the aortic arch and stomach is concordant

growth/size/body

right-sided stomach ( J:104135 )

• at E18.5, 10 of 16 homozygotes display a right-sided stomach

• the sidedness of the aortic arch and stomach is concordant

left pulmonary isomerism ( J:104135 )

• at E18.5, 1 of 16 homozygotes displays left pulmonary isomerism

lung situs inversus ( J:104135 )

• at E18.5, >50% of homozygotes display a reversal of lung laterality resulting in a single-lobed right lung and a four-lobed left lung

right pulmonary isomerism ( J:104135 )

• at E18.5, 3 of 16 homozygotes display right pulmonary isomerism