Phenotypes Associated with This Genotype

Genotype
MGI:4889194

• Allelic Composition: Foxj1^tm1Bph/Foxj1^tm1Bph; Invs^inv/Invs^inv
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

right pulmonary isomerism ( J:104135 )

• at E18.5, nearly all (18 of 21) double homozygotes display right pulmonary isomerism

• right pulmonary isomerism is likely due to absence of Pitx2 expression in both lateral plate mesoderms at E8.5

cardiovascular system

right aortic arch ( J:104135 )

• at E18.5, 10 of 21 double homozygotes display a right-sided aortic arch

• the remaining 11 show a normal left-sided aortic arch

aorta hypoplasia ( J:104135 )

• at E18.5, 3 of the 11 double homozygotes with a normal left-sided aortic arch display an underdeveloped aorta

digestive/alimentary system

right-sided stomach ( J:104135 )

• at E18.5, 61% of double homozygotes display a right-sided stomach

• no colinearity of the sidedness between the aortic arch and stomach is observed

growth/size/body

right-sided stomach ( J:104135 )

• at E18.5, 61% of double homozygotes display a right-sided stomach

• no colinearity of the sidedness between the aortic arch and stomach is observed

right pulmonary isomerism ( J:104135 )

• at E18.5, nearly all (18 of 21) double homozygotes display right pulmonary isomerism

• right pulmonary isomerism is likely due to absence of Pitx2 expression in both lateral plate mesoderms at E8.5