Analysis Tools
respiratory system
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• homozygotes show postnatal lung alveolarization defects, at least partly due to increased expression of Pdpn (T1alpha), a marker of type I alveolar epithelial cells
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• at P8 and P20, mutant lungs exhibit severely dilated distal airspaces, as shown by mean linear intercept analysis
• however, no significant changes in alveolar epithelial cell morphology are noted at P8
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• at P8 and P20, mutant lungs display severely dilated airways
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