Phenotypes Associated with This Genotype

Genotype
MGI:4889076

• Allelic Composition: Kif20b^magoo/Kif20b^magoo; Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:168258 )

nervous system

abnormal axon extension ( J:168258 )

• mice exhibit occasional ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice

forebrain hypoplasia ( J:168258 )

• slightly small

abnormal telencephalon morphology ( J:168258 )

• mice exhibit occasional ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice

enlarged lateral ventricles ( J:168258 )

absent olfactory bulb ( J:168258 )

• in some mice

small olfactory bulb ( J:168258 )

• in some mice

vision/eye

iris coloboma ( J:168258 )

• in 38 of 46 mice

microphthalmia ( J:168258 )

• in 38 of 46 mice

craniofacial

abnormal craniofacial morphology ( J:168258 )

cleft palate ( J:168258 )

• in 10 of 42 mice

short snout ( J:168258 )

limbs/digits/tail

abnormal digit morphology ( J:168258 )

• in 13% of mice

digestive/alimentary system

cleft palate ( J:168258 )

• in 10 of 42 mice

cellular

abnormal axon extension ( J:168258 )

• mice exhibit occasional ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice

growth/size/body

cleft palate ( J:168258 )

• in 10 of 42 mice

short snout ( J:168258 )

microcephaly ( J:168258 )

• small head