Phenotypes Associated with This Genotype

Genotype
MGI:4888688

• Allelic Composition: \Aplf^{Gt(RRF189)Byg}/\Aplf^{Gt(RRF189)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal DNA repair ( J:168260 )

• B cells exhibit an increased in microhomology at class switch recombination junctions compared with wild-type cells

immune system

abnormal class switch recombination ( J:168260 )

• following gamma irradiation, gamma-H2AX foci decline at a reduced rate in mouse embryonic fibroblasts compared to in wild-type cells

homeostasis/metabolism

abnormal DNA repair ( J:168260 )

• B cells exhibit an increased in microhomology at class switch recombination junctions compared with wild-type cells

hematopoietic system

abnormal class switch recombination ( J:168260 )

• following gamma irradiation, gamma-H2AX foci decline at a reduced rate in mouse embryonic fibroblasts compared to in wild-type cells