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Phenotypes Associated with This Genotype
Genotype
MGI:4888545
Allelic
Composition
Sfntm1Mak/Sfntm1Mak
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfntm1Mak mutation (0 available); any Sfn mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in vesicular stomatitis virus (VSV)-infected mice

immune system
N
• mice exhibit normal T cell dependent immune response
• when cells are used in adoptive transfer experiments in Rag1 null mice
• in uninduced and BCR-stimulated mice
• adoptive transfer experiments confirm that the defects in B cell homeostasis is B cell intrinsic
• recirculating B cells are decreased compared to in wild-type mice
• splenic B cells are decreased compared to in wild-type mice
• the splenic B cell zone is smaller, the T cell zone is not consistently surrounded by B cells, the follicular B cell area is smaller, and the marginal zone B cell area is absent compared to in wild-type mice
• in vesicular stomatitis virus (VSV)-infected mice
• following TNP-Ficoll injection
• vesicular stomatitis virus (VSV)-infected mice exhibit decreased IgG levels and increased mortality compared with similarly treated wild-type mice
• in vesicular stomatitis virus (VSV)-infected mice

hematopoietic system
• when cells are used in adoptive transfer experiments in Rag1 null mice
• in uninduced and BCR-stimulated mice
• adoptive transfer experiments confirm that the defects in B cell homeostasis is B cell intrinsic
• recirculating B cells are decreased compared to in wild-type mice
• splenic B cells are decreased compared to in wild-type mice
• the splenic B cell zone is smaller, the T cell zone is not consistently surrounded by B cells, the follicular B cell area is smaller, and the marginal zone B cell area is absent compared to in wild-type mice
• in vesicular stomatitis virus (VSV)-infected mice
• following TNP-Ficoll injection

cellular
• when cells are used in adoptive transfer experiments in Rag1 null mice
• in uninduced and BCR-stimulated mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory