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Phenotypes Associated with This Genotype
Genotype
MGI:4888512
Allelic
Composition
Btdtm1Bwol/Btdtm1Bwol
Genetic
Background
B6.Cg-Btdtm1Bwol
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btdtm1Bwol mutation (0 available); any Btd mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice fed a biotin-deprived diet exhibit behavioral and neurological symptoms unlike similarly treated wild-type mice (J:168391)
• mice fed a biotin-deprived diet exhibit behavioral and neurological symptoms unlike similarly treated wild-type mice (J:168391)
• by day 14 in mice fed a biotin-depleted diet (J:168391)
• however, biotin-treatment rescues tremors (J:168391)
• by day 14 in mice fed a biotin-depleted diet (J:168391)
• however, biotin-treatment rescues tremors (J:168391)
• by day 14, mice fed a biotin-depleted diet exhibit tail and limb weakness unlike similarly treated wild-type mice (J:168391)
• by day 16, mice fed a biotin-depleted diet exhibit limb weakness to paralysis unlike similarly treated wild-type mice (J:168391)
• by day 14, mice fed a biotin-depleted diet exhibit tail and limb weakness unlike similarly treated wild-type mice (J:168391)
• by day 16, mice fed a biotin-depleted diet exhibit limb weakness to paralysis unlike similarly treated wild-type mice (J:168391)
• by day 14 in mice fed a biotin-depleted diet (J:168391)
• by day 14 in mice fed a biotin-depleted diet (J:168391)
• by day 14 in mice fed a biotin-depleted diet (J:168391)
• by day 14 in mice fed a biotin-depleted diet (J:168391)
• by day 14 in mice fed a biotin-depleted diet (J:168391)
• by day 14 in mice fed a biotin-depleted diet (J:168391)
• by day 16 in mice fed a biotin-depleted diet (J:168391)
• by day 16 in mice fed a biotin-depleted diet (J:168391)
• by day 16 in mice fed a biotin-depleted diet (J:168391)
• by day 16 in mice fed a biotin-depleted diet (J:168391)

integument
• by day 14, mice fed a biotin-depleted diet exhibit whitening of the fur around the eyes and subsequent graying of the fur over the entire body unlike similarly treated wild-type mice (J:168391)
• by day 14, mice fed a biotin-depleted diet exhibit whitening of the fur around the eyes and subsequent graying of the fur over the entire body unlike similarly treated wild-type mice (J:168391)
• in mice fed a biotin-depleted diet (J:168391)
• however, treatment with biotin restores coat (J:168391)
• in mice fed a biotin-depleted diet (J:168391)
• however, treatment with biotin restores coat (J:168391)

homeostasis/metabolism
• in mice fed a biotin-depleted diet (J:168391)
• in mice fed a biotin-depleted diet (J:168391)
• mice fed a biotin-depleted diet exhibit increased urinary biotin and biotin metabolites and 3-hydroxyisovaleric acid (20-fold) compared with similarly treated wild-type mice (J:168391)
• mice fed a biotin-depleted diet exhibit increased urinary biotin and biotin metabolites and 3-hydroxyisovaleric acid (20-fold) compared with similarly treated wild-type mice (J:168391)

growth/size/body
• in mice fed a biotin-depleted diet (J:168391)
• however, biotin treatment reverses weight loss (J:168391)
• in mice fed a biotin-depleted diet (J:168391)
• however, biotin treatment reverses weight loss (J:168391)

skeleton
• in mice fed a biotin-depleted diet (J:168391)
• in mice fed a biotin-depleted diet (J:168391)

renal/urinary system
• mice fed a biotin-depleted diet exhibit increased urinary biotin and biotin metabolites and 3-hydroxyisovaleric acid (20-fold) compared with similarly treated wild-type mice (J:168391)
• mice fed a biotin-depleted diet exhibit increased urinary biotin and biotin metabolites and 3-hydroxyisovaleric acid (20-fold) compared with similarly treated wild-type mice (J:168391)

muscle
• in mice fed a biotin-depleted diet (J:168391)
• in mice fed a biotin-depleted diet (J:168391)

vision/eye
• mice fed a biotin-depleted diet exhibit a difficult time keeping eyelids open unlike similarly treated wild-type mice (J:168391)
• mice fed a biotin-depleted diet exhibit a difficult time keeping eyelids open unlike similarly treated wild-type mice (J:168391)

pigmentation
• by day 14, mice fed a biotin-depleted diet exhibit whitening of the fur around the eyes and subsequent graying of the fur over the entire body unlike similarly treated wild-type mice (J:168391)
• by day 14, mice fed a biotin-depleted diet exhibit whitening of the fur around the eyes and subsequent graying of the fur over the entire body unlike similarly treated wild-type mice (J:168391)

Mouse Models of Human Disease
OMIM ID Ref(s)
Biotinidase Deficiency 253260 J:168391


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory