Phenotypes Associated with This Genotype

Genotype
MGI:4888387

• Allelic Composition: Lamtor1^tm1Moka/Lamtor1^tm1Moka
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:168293 )

• at the egg cylinder stage around E7

embryo

embryonic growth arrest ( J:168293 )

• at E7

abnormal extraembryonic endoderm formation ( J:168293 )

• the apical surface is expanded with accumulation of small LAP-1+ vesicles and tubular endosome-related organelles beneath the apical membrane unlike in wild-type mice

abnormal visceral endoderm morphology ( J:168293 )

• cells from the visceral endoderm of E7 embryos exhibit small lysosomal structures with amorphous substances unlike in wild-type mice

cellular

abnormal lysosome morphology ( J:168293 )

• cells from the visceral endoderm of E7 embryos exhibit small lysosomal structures with amorphous substances unlike in wild-type mice