Phenotypes Associated with This Genotype

Genotype
MGI:4887975

• Allelic Composition: Tg(Col1a1-Runx2)#Pmt/0; Tg(Eno2tTA)#Nes/0; Tg(tetO-Zfp521)#Rbar/0
• Genetic Background: involves: BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:167992 )

N • nearly all aspects of the Tg(Col1a1-Runx2)#Pmt phenotype are reversed

decreased compact bone thickness ( J:167992 )

decreased osteocyte number ( J:167992 )

• osteocyte numbers in the cortical bone are reduced compared to in wild-type mice but not as severely as in Tg(Col1a1-Runx2)#Pmt mice

abnormal bone mineralization ( J:167992 )

• mice exhibit reduced cortical mineral apposition rates compared with wild-type mice

fragile skeleton ( J:167992 )

• fracture rate is increased compared to in wild-type mice but not as severely as in Tg(Col1a1-Runx2)#Pmt mice