Phenotypes Associated with This Genotype

Genotype
MGI:4887974

• Allelic Composition: Tg(Col1a1-Runx2)#Pmt/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoblast differentiation ( J:167992 )

• mice exhibit impaired osteoblast maturation compared with wild-type mice

increased osteoclast cell number ( J:167992 )

• in the trabecular bone

abnormal compact bone morphology ( J:167992 )

• the cortices are highly porous unlike in wild-type mice

decreased compact bone thickness ( J:167992 )

increased osteoblast cell number ( J:167992 )

• in the trabecular bone

decreased osteocyte number ( J:167992 )

• osteocyte numbers in the cortical bone are reduced compared to in wild-type mice

decreased bone mass ( J:167992 )

abnormal bone ossification ( J:167992 )

• bone formation rate is reduced compared to in wild-type mice

abnormal bone mineralization ( J:167992 )

• mice exhibit reduced cortical mineral apposition rates compared with wild-type mice

fragile skeleton ( J:167992 )

immune system

increased osteoclast cell number ( J:167992 )

• in the trabecular bone

hematopoietic system

increased osteoclast cell number ( J:167992 )

• in the trabecular bone

cellular

abnormal osteoblast differentiation ( J:167992 )

• mice exhibit impaired osteoblast maturation compared with wild-type mice