Phenotypes Associated with This Genotype

Genotype
MGI:4887972

• Allelic Composition: Tg(Eno2tTA)#Nes/0; Tg(tetO-Zfp521)#Rbar/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased hyoid bone size ( J:167992 )

• the mineralized midpoint of the hyoid bone is decreased in length compared to in wild-type mice

• however, mineralization occurs unlike in Runx2^tm1Mjo heterozygotes

clavicle hypoplasia ( J:167992 )

• clavicle is smaller than in wild-type mice but not as severely reduced as in Runx2^tm1Mjo heterozygotes

increased bone volume ( J:167992 )

• mice exhibit an increase in bone volume compared with wild-type mice

abnormal trabecular bone morphology ( J:167992 )

• mice exhibit an increase in bone volume and trabeculae number and a decrease in trabecular space compared with wild-type mice

increased bone mass ( J:167992 )

• mice exhibit an increase in bone mass compared with wild-type mice

increased bone ossification ( J:167992 )

• mice exhibit increased bone formation compared to in wild-type mice

craniofacial

decreased hyoid bone size ( J:167992 )

• the mineralized midpoint of the hyoid bone is decreased in length compared to in wild-type mice

• however, mineralization occurs unlike in Runx2^tm1Mjo heterozygotes