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Phenotypes Associated with This Genotype
Genotype
MGI:4887891
Allelic
Composition
Tg(Plp)66Kan/Tg(Plp)66Kan
Genetic
Background
B6NCrl.Cg-Tg(Plp)66Kan
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die prior to P60

behavior/neurological
• mutants exhibit tremor starting at 2 weeks of age, followed later by seizures
• mutants develop seizures following tremors

nervous system
• mutants develop seizures following tremors
• mutants exhibit an increase in the number of apoptotic oligodendrocytes by P20
• oligodendrocytes show swelling of the Golgi apparatus and numerous autophagic vacuoles by P20
• markedly thinner myelin sheath
• mutants exhibit marked dymyelination by P20

cellular
• mutants exhibit an increase in the number of apoptotic oligodendrocytes by P20

Mouse Models of Human Disease
OMIM ID Ref(s)
Pelizaeus-Merzbacher Disease; PMD 312080 J:156106


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory