Phenotypes Associated with This Genotype

Genotype
MGI:4887401

• Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc
• Genetic Background: involves: 129P2/OlaHsd * 129/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:98065 )

• 100% perinatal death

respiratory system

abnormal lung morphology ( J:98065 )

• at E18.5, mutant lungs display a significantly more condensed tissue morphology than wild-type lungs

increased lung weight ( J:98065 )

• at E18.5, mutant lung wet weight to body weight ratio is significantly increased

pulmonary hyperplasia ( J:98065 )

• at E18.5, lung wet weight and DNA content are significantly higher in mutant lungs, indicating significant hypercellularity

abnormal lung development ( J:98065 )

• mutants display altered development of the terminal respiratory units of the lung

abnormal pulmonary alveolus morphology ( J:98065 )

• at E18.5, mutant lungs lack normal airspace formation

abnormal pulmonary alveolus epithelial cell morphology ( J:98065 )

• at E18.5, mutant lungs display altered alveolar epithelial cell differentiation, primarily causing a reduction in the number of differentiated type I epithelial cells

decreased type I pneumocyte number ( J:98065 )

• at E18.5, the proportions of type-I cells are reduced by ~50%

• a 50% decrease in mRNA levels for T1alpha and aquaporin-5 (two type I cell-specific markers) is observed

increased type II pneumocyte number ( J:98065 )

• at E18.5, the proportions of type II cells are increased by ~30%

abnormal alveolocapillary membrane morphology ( J:98065 )

• at E18.5, mutant lungs show significantly thicker air/blood gas diffusion barriers, with multiple cellular compartments between the airways and adjacent capillaries

• no evidence of epithelial cell and endothelial cell basement membrane fusion is observed

• airway to capillary diffusion distance is increased 6-fold

thick pulmonary interalveolar septum ( J:98065 )

• at E18.5, mutant lungs display thickened interalveolar septa

abnormal surfactant secretion ( J:98065 )

• at E18.5, mRNA levels of type II epithelial cell surfactant protein genes A and C are reduced by ~50%

homeostasis/metabolism

increased circulating corticosterone level ( J:98065 )

• at E18.5, circulating levels of plasma corticosterone are increased by >3-fold relative to those in wild-type controls

growth/size/body

increased lung weight ( J:98065 )

• at E18.5, mutant lung wet weight to body weight ratio is significantly increased

pulmonary hyperplasia ( J:98065 )

• at E18.5, lung wet weight and DNA content are significantly higher in mutant lungs, indicating significant hypercellularity