Mouse Genome Informatics
ht
    Ryr1tm2.1Alle/Ryr1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
respiratory system
• rate increase from 147 to about 183 breaths per minute
• resulting from halothane anesthesia

homeostasis/metabolism
• drop in blood pH during anesthesia is significantly greater than for controls
• blood lactate increase is significantly greater during anesthesia than for controls
• hyperthermia followed by death during "recovery" period after halothane anesthesia
• pretreatment with muscle relaxants (dantrolene) eliminates symptoms of malignant hyperthermia during and following halothane exposure
• response to 42C exposure is similar to response to halothane
• pCO2 is significantly greater than for controls during anesthesia
• calcium response of muscle cells to caffeine at lower caffeine concentrations (increased sensitivity)
• resting calcium ion concentration in myotubes is significantly higher than in controls
• hyperthermia and death usually occurs during recovery from halothane anesthesia

other phenotype
• do not tolerate orbital blood collection well
• 50 % mortality during blood collection under halothane anesthesia
• hyperacute rigor mortis within 0.34 minutes of death, full body contracture

mortality/aging
• hyperthermia and death usually occurs during recovery from halothane anesthesia

Mouse Models of Human Disease
OMIM IDRef(s)
Malignant Hyperthermia, Susceptibility to, 1; MHS1 145600 J:168222