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Phenotypes Associated with This Genotype
Genotype
MGI:4887395
Allelic
Composition
Ryr1tm2.1Alle/Ryr1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr1tm2.1Alle mutation (0 available); any Ryr1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• resulting from halothane anesthesia (J:168222)
• rate increase from 147 to about 183 breaths per minute (J:168222)
• resulting from halothane anesthesia (J:168222)
• rate increase from 147 to about 183 breaths per minute (J:168222)

homeostasis/metabolism
• drop in blood pH during anesthesia is significantly greater than for controls (J:168222)
• blood lactate increase is significantly greater during anesthesia than for controls (J:168222)
• drop in blood pH during anesthesia is significantly greater than for controls (J:168222)
• blood lactate increase is significantly greater during anesthesia than for controls (J:168222)
• pCO2 is significantly greater than for controls during anesthesia (J:168222)
• pCO2 is significantly greater than for controls during anesthesia (J:168222)
• calcium response of muscle cells to caffeine at lower caffeine concentrations (increased sensitivity) (J:168222)
• resting calcium ion concentration in myotubes is significantly higher than in controls (J:168222)
• calcium response of muscle cells to caffeine at lower caffeine concentrations (increased sensitivity) (J:168222)
• resting calcium ion concentration in myotubes is significantly higher than in controls (J:168222)
• do not tolerate orbital blood collection well (J:168222)
• 50 % mortality during blood collection under halothane anesthesia (J:168222)
• hyperacute rigor mortis within 0.34 minutes of death, full body contracture (J:168222)
• do not tolerate orbital blood collection well (J:168222)
• 50 % mortality during blood collection under halothane anesthesia (J:168222)
• hyperacute rigor mortis within 0.34 minutes of death, full body contracture (J:168222)
• hyperthermia followed by death during "recovery" period after halothane anesthesia (J:168222)
• pretreatment with muscle relaxants (dantrolene) eliminates symptoms of malignant hyperthermia during and following halothane exposure (J:168222)
• response to 42C exposure is similar to response to halothane (J:168222)
• hyperthermia followed by death during "recovery" period after halothane anesthesia (J:168222)
• pretreatment with muscle relaxants (dantrolene) eliminates symptoms of malignant hyperthermia during and following halothane exposure (J:168222)
• response to 42C exposure is similar to response to halothane (J:168222)

mortality/aging
• do not tolerate orbital blood collection well (J:168222)
• 50 % mortality during blood collection under halothane anesthesia (J:168222)
• hyperacute rigor mortis within 0.34 minutes of death, full body contracture (J:168222)
• do not tolerate orbital blood collection well (J:168222)
• 50 % mortality during blood collection under halothane anesthesia (J:168222)
• hyperacute rigor mortis within 0.34 minutes of death, full body contracture (J:168222)
• hyperthermia followed by death during "recovery" period after halothane anesthesia (J:168222)
• pretreatment with muscle relaxants (dantrolene) eliminates symptoms of malignant hyperthermia during and following halothane exposure (J:168222)
• response to 42C exposure is similar to response to halothane (J:168222)
• hyperthermia followed by death during "recovery" period after halothane anesthesia (J:168222)
• pretreatment with muscle relaxants (dantrolene) eliminates symptoms of malignant hyperthermia during and following halothane exposure (J:168222)
• response to 42C exposure is similar to response to halothane (J:168222)

Mouse Models of Human Disease
OMIM ID Ref(s)
Malignant Hyperthermia, Susceptibility to, 1; MHS1 145600 J:168222


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory