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Phenotypes Associated with This Genotype
Genotype
MGI:4887392
Allelic
Composition		 Mbd3tm2Bh/Mbd3tm2Bh
Tg(Vil1-cre)20Syr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbd3tm2Bh mutation (2 available); any Mbd3 mutation (58 available)
Tg(Vil1-cre)20Syr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal small intestinal crypt cell proliferation ( J:167984 )
• increase in intestinal progenitor cell proliferation in the crypts
increased susceptibility to induced colitis ( J:167984 )
• large increase in proliferating cells compared to controls following DSS treatment

neoplasm
increased incidence of tumors by chemical induction ( J:167984 )
• striking increase in the number of tumors in mice following azoxymethane and DSS treatment
increased tumor growth/size ( J:167984 )
• tumors induced by azoxymethane and DSS treatment are increased in size compared to controls

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:167984 )
• striking increase in the number of tumors in mice following azoxymethane and DSS treatment

immune system
increased susceptibility to induced colitis ( J:167984 )
• large increase in proliferating cells compared to controls following DSS treatment

cellular
abnormal small intestinal crypt cell proliferation ( J:167984 )
• increase in intestinal progenitor cell proliferation in the crypts

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory