Analysis Tools
reproductive system
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• in response to 17-beta-estradiol treatment, apoptosis in uterine glandular and luminal epithelium is significantly increased by 3 days post-treatment in mutants compared to treated wild-type
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• in response to 17-beta-estradiol treatment, uterine weight increases in ovariectomized mutants but not as significantly as in ovariectomized wild-type females at 24 hours and 3 days after treatment
• uterine proliferative response to ICI 182,780 (estrogen antagonist) is fully attenuated in wild-type and mutant females
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• in mutants, 0 of 6 implantation sites are observed following natural matings or embryo transfer in contrast to wild-type females where 6 of 9 implantation sites are detected
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