Phenotypes Associated with This Genotype

Genotype
MGI:4882131

• Allelic Composition: Fam3b^tm1Bkht/Fam3b^tm1Bkht
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:167823 )

N • normal 24 and 48 hour fasting levels of glucose, insulin and glucagon

abnormal glucose homeostasis ( J:167823 )

• reduced hepatic glucose production during a hyperinsulinemic-euglycemic clamp

decreased insulin secretion ( J:167823 )

• decreased insulin secretion response by isolated islets exposed to increased glucose concentrations

increased circulating insulin level ( J:167823 )

• elevated insulin after glucose injection

impaired glucose tolerance ( J:167823 )

• male mice show higher blood glucose in glucose tolerance tests at 4 and 6 months of age

• glucose intolerance in 3 month old male mice

abnormal insulin clearance ( J:167823 )

• impaired insulin clearance as indicated by a reduced C-peptide to insulin ratio

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:167823 )

N • normal islet architecture

decreased insulin secretion ( J:167823 )

• decreased insulin secretion response by isolated islets exposed to increased glucose concentrations