Phenotypes Associated with This Genotype

Genotype
MGI:4882102

• Allelic Composition: Ofd1^tm2.1Bfra/Ofd1⁺; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

preaxial polydactyly ( J:168038 )

♀ • in the first digit in each forelimb but not hindlimb

abnormal humerus morphology ( J:168038 )

♀ • at E16.5, the bone collar of the humerus is slightly reduced compared to in wild-type mice

short humerus ( J:168038 )

♀

short radius ( J:168038 )

♀

short ulna ( J:168038 )

♀

short femur ( J:168038 )

♀

short fibula ( J:168038 )

♀

short tibia ( J:168038 )

♀

abnormal limb development ( J:168038 )

♀ • axoneme doublets are missing in the limb mesenchyme cilia unlike in wild-type mice

abnormal limb mesenchyme morphology ( J:168038 )

♀ • axoneme doublets are missing in the limb mesenchyme cilia unlike in wild-type mice

embryo

abnormal limb mesenchyme morphology ( J:168038 )

♀ • axoneme doublets are missing in the limb mesenchyme cilia unlike in wild-type mice

skeleton

abnormal humerus morphology ( J:168038 )

♀ • at E16.5, the bone collar of the humerus is slightly reduced compared to in wild-type mice

short humerus ( J:168038 )

♀

short radius ( J:168038 )

♀

short ulna ( J:168038 )

♀

short femur ( J:168038 )

♀

short fibula ( J:168038 )

♀

short tibia ( J:168038 )

♀