Phenotypes Associated with This Genotype

Genotype
MGI:4881929

• Allelic Composition: Actg1^tm1.2Erv/Actg1^tm1.2Erv; Tg(ACTA1-cre)79Jme/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:112808 )

• about 2/3 of mice show classical hind limb contractures when suspended by the tail

• persists throughout life without getting any worse

decreased locomotor activity ( J:112808 )

• reduced mobility

• persists throughout life without getting any worse

muscle

abnormal Z line morphology ( J:112808 )

• dystrophin is less organized at the z-line in some muscles

abnormal skeletal muscle fiber morphology ( J:112808 )

• muscles primarily made up of type II fibers are most affected

increased variability of skeletal muscle fiber size ( J:112808 )

• more variability in muscle fiber size

centrally nucleated skeletal muscle fibers ( J:112808 )

• centrally nucleated fibers start appearing in muscle at about 3 months of age and progress to widespread incidence by 12 to 18 months

impaired skeletal muscle contractility ( J:112808 )

• maximal force production by extensor digitorum longus muscle is less than in controls

• maximal titanic force is similar to controls