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Phenotypes Associated with This Genotype
Genotype
MGI:4881775
Allelic
Composition
Lmx1btm1Zfc/Lmx1btm1Zfc
Tg(Fev-cre/ERT2)#Yqd/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1btm1Zfc mutation (0 available); any Lmx1b mutation (16 available)
Tg(Fev-cre/ERT2)#Yqd mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• after tamoxifen induction at P90, brain levels of 5-HT (serotonin) and its metabolite 5-HIAA are reduced to about 60% and 30% of control levels respectively 2-3 weeks after the last dose
• normal: levels of other monoamines in the brain, including norepinephrine and dopamine are unchanged by deletion of Lmx1b in the raphe nuclei


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory