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Phenotypes Associated with This Genotype
Genotype
MGI:4881696
Allelic
Composition		 \Plxnb2tm1Matl/\Plxnb2tm1Matl
\Sema4ctm1Matl/\Sema4ctm1Matl
Genetic
Background		 B6.129P2-Sema4ctm1Matl Plxnb2tm1Matl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb2tm1Matl mutation (2 available); any Plxnb2 mutation (90 available)
Sema4ctm1Matl mutation (0 available); any Sema4c mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellar granule cell migration ( J:167973 )
• in a transwell assay with stromal cell line-derived factor-1alpha (SDF-1alpha) or brain derived neurotrophic factor (BDNF), granule cell precursors exhibit impaired migration compared with wild-type cells and cells form Sema4ctm1Matl homozygotes
abnormal cerebellar granule layer morphology ( J:167973 )
• the internal granule layer of lobules II and III is disrupted compared to in wild-type mice and more severely disrupted compared to in Sema4ctm1Matl homozygotes

cellular
abnormal cerebellar granule cell migration ( J:167973 )
• in a transwell assay with stromal cell line-derived factor-1alpha (SDF-1alpha) or brain derived neurotrophic factor (BDNF), granule cell precursors exhibit impaired migration compared with wild-type cells and cells form Sema4ctm1Matl homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory