Phenotypes Associated with This Genotype

Genotype
MGI:4881693

• Allelic Composition: Sema4c^tm1Matl/Sema4c^tm1Matl
• Genetic Background: B6.129P2-Sema4c^tm1Matl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:167973 )

• mice with exencephaly die shortly after first

nervous system

abnormal cerebellar granule cell migration ( J:167973 )

• migration of granule cell precursors (GCPs) out of an explant is reduced compared to in wild-type explants

• however, GCP migration in a transwell assay with stromal cell line-derived factor-1alpha (SDF-1alpha) or brain derived neurotrophic factor (BDNF) is normal

abnormal cerebellar granule layer morphology ( J:167973 )

• 50% of mice exhibit gaps in the granule layer of lobule II unlike wild-type mice

ectopic cerebellar granule cells ( J:167973 )

• 60% of mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice

abnormal cerebellum lobule morphology ( J:167973 )

• 80% of mice exhibit rostral lobules VIII and IX fusion with disruption of the basal lamina at the site of fusion unlike in wild-type mice

exencephaly ( J:167973 )

• in one third of mice

pigmentation

belly spot ( J:167973 )

• white patches along the ventral midline

integument

belly spot ( J:167973 )

• white patches along the ventral midline

cellular

abnormal cerebellar granule cell migration ( J:167973 )

• migration of granule cell precursors (GCPs) out of an explant is reduced compared to in wild-type explants

• however, GCP migration in a transwell assay with stromal cell line-derived factor-1alpha (SDF-1alpha) or brain derived neurotrophic factor (BDNF) is normal

renal/urinary system

renal/urinary system phenotype ( J:221423 )

N • mice show normal kidney morphology and a normal response to kidney ischemia/reperfusion injury