Phenotypes Associated with This Genotype

Genotype
MGI:4881534

• Allelic Composition: Cngb1^tm1.1Glf/Cngb1^tm1.1Glf; Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc
• Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal rod electrophysiology ( J:166744 )

• as in mice homozygous for Guca1a/Guca1b^tm1Jnc alone, flash sensitivity declines more rapidly as a function of background light intensity compared to wild-type mice

• when dark adapted rods are exposed to prolonged steps of light of varying duration the initial rapid decrease in circulating current seen in wild-type rods is absent but a slower current increase is seen and the turning off of light produces a transient overshoot

• the amplitudes of the slow recovery phase and of the overshoot are somewhat larger than in mice homozygous for Guca1a/Guca1b^tm1Jnc alone