Phenotypes Associated with This Genotype

Genotype
MGI:4880724

• Allelic Composition: Fadd^tm1Mpa/Fadd^tm1Mpa; Mog^tm1(cre)Gkl/Mog⁺
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:167475 )

N • peripheral T cell activation is normal

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:167475 )

• MOG35-55-treated mice exhibit less severe disease and reduced oligodendrocyte apoptosis compared with similarly treated wild-type mice

• however, MOG35-55-treated mice exhibit normal T cell activation

nervous system

nervous system phenotype ( J:167475 )

N • mice exhibit normal myelination

abnormal oligodendrocyte apoptosis ( J:167475 )

• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice

• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice

cellular

abnormal oligodendrocyte apoptosis ( J:167475 )

• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice

• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice