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Phenotypes Associated with This Genotype
Genotype
MGI:4880014
Allelic
Composition		 Pld2tm1.1Gdp/Pld2tm1.1Gdp
Tg(APPSWE)2576Kha/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld2tm1.1Gdp mutation (1 available); any Pld2 mutation (47 available)
Tg(APPSWE)2576Kha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:166741 )
N
• mice exhibit normal spatial working memory unlike Tg(APPSWE)2576Kha mice
enhanced contextual conditioning behavior ( J:166741 )
• compared to Tg(APPSWE)2576Kha mice

homeostasis/metabolism
abnormal lipid level ( J:166741 )
• mice exhibit altered levels of specific phosphatidic acids compared to in wild-type mice

nervous system
abnormal synapse morphology ( J:166741 )
• mice exhibit synaptic protection compared to in Tg(APPSWE)2576Kha mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory