Phenotypes Associated with This Genotype

Genotype
MGI:4880007

• Allelic Composition: Napa^hyh/Napa^hyh; Napb^tm1Bros/Napb^tm1Bros
• Genetic Background: involves: C57BL/10J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:167753 )

nervous system

decreased synaptic vesicle readily releasable pool size ( J:167753 )

• the pool of readily releasable vesicles is smaller than in control neurons

• stimulated total release and extrapolated pool of readily releasable vesicles is smaller than in control neurons

abnormal neuron physiology ( J:167753 )

• the slow release phase of synaptic vesicles is reduced compared to in wild-type neurons

• total charge transfer induced by calcimycin application is less than in similarly treated control neurons

abnormal excitatory postsynaptic currents ( J:167753 )

• following an action potential train, excitatory postsynaptic current depression is faster and stronger than in control neurons

cellular

decreased synaptic vesicle readily releasable pool size ( J:167753 )

• the pool of readily releasable vesicles is smaller than in control neurons

• stimulated total release and extrapolated pool of readily releasable vesicles is smaller than in control neurons