Phenotypes Associated with This Genotype

Genotype
MGI:4879106

• Allelic Composition: Tsc1^tm1Djk/Tsc1^tm1Djk
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

enlarged liver ( J:167208 )

• about a 40% increase in liver mass following adenoviral cre retro-orbital injection

abnormal hepatocyte morphology ( J:167208 )

• increase in hepatocyte size following adenoviral cre retro-orbital injection

abnormal liver physiology ( J:167208 )

• decrease in liver protein content following adenoviral cre retro-orbital injection

• in cre injected mice, the liver is largely refractory to fast induced shrinkage

• cre injected mice are unable to generate ketones when given sodium octanoate

homeostasis/metabolism

decreased circulating ketone body level ( J:167208 )

• markedly lower serum ketones in young fasted cre injected mice but not in aged fasted cre injected mice

decreased body temperature ( J:167208 )

• in fasted cre injected mice

behavior/neurological

decreased locomotor activity ( J:167208 )

• in fasted cre injected mice

growth/size/body

enlarged liver ( J:167208 )

• about a 40% increase in liver mass following adenoviral cre retro-orbital injection