Phenotypes Associated with This Genotype

Genotype
MGI:4879021

• Allelic Composition: Stat3^tm1Xyfu/Stat3⁺; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased tumor necrosis factor secretion ( J:86400 )

• in the cardiac myocytes of LPS-treated mice

increased susceptibility to endotoxin shock ( J:86400 )

• LPS-treated mice exhibit increased TNF-alpha levels in cardiac myocytes compared with similarly treated wild-type mice although not as severely as in homozygous mice

cardiovascular system

cardiac fibrosis ( J:86400 )

• severe at 9 months