Phenotypes Associated with This Genotype

Genotype
MGI:4879003

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Fto)Rdc}/Gt(ROSA)26Sor^{tm1.1(CAG-Fto)Rdc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased lean body mass ( J:166829 )

increased body weight ( J:166829 )

• detected in females by 4 weeks of age

• females are about 22% heavier than control littermates at 20 weeks of age

• males are about 11% heavier than control littermates at 20 weeks of age

increased susceptibility to diet-induced obesity ( J:166829 )

• increased weight gain on a high fat diet compared to diet matched controls

• increase in fat mass on a high fat diet is more pronounced in females

behavior/neurological

increased food intake ( J:166829 )

• increase in food intake on both standard and high fat diets

adipose tissue

increased total body fat amount ( J:166829 )

• increase in fat mass in both males and females

• increase is greater than in heterozygous mice

• increase in fat mass on a high fat diet is more pronounced in females

increased abdominal fat pad weight ( J:166829 )

• increase in epigonadal and abdominal white adipose tissues

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:166829 )

• increased weight gain on a high fat diet compared to diet matched controls

• increase in fat mass on a high fat diet is more pronounced in females

abnormal circulating lipid level ( J:166829 )

increased circulating HDL cholesterol level ( J:166829 )

♀ • in females at 20 weeks of age

decreased circulating LDL cholesterol level ( J:166829 )

♀ • in females at 20 weeks of age

increased circulating free fatty acids level ( J:166829 )

♀ • in females at 20 weeks of age

increased circulating triglyceride level ( J:166829 )

♀ • in females at 20 weeks of age

increased energy expenditure ( J:166829 )

• on a standard diet during both the light and dark periods

impaired glucose tolerance ( J:166829 )

• in mice on a high fat diet relative to diet matched controls

abnormal hormone level ( J:166829 )

increased circulating insulin level ( J:166829 )

♂ • increase in fasting insulin levels in males on a high fat diet at 16 weeks of age

decreased circulating leptin level ( J:166829 )

• in males and females at 8 weeks of age after a 16 h fast

decreased adiponectin level ( J:166829 )

• in females on a high fat diet and in males on a standard diet