Phenotypes Associated with This Genotype

Genotype
MGI:4868736

• Allelic Composition: Dmbt1^tm2Qaa/Dmbt1^tm2Qaa; Tg(ATP6V1B1-cre)45Rnel/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating bicarbonate level ( J:167156 )

metabolic acidosis ( J:167156 )

• metabolic acidosis

renal tubular acidosis ( J:167156 )

increased urine pH ( J:167156 )

renal/urinary system

renal tubular acidosis ( J:167156 )

increased urine pH ( J:167156 )

abnormal kidney cortex morphology ( J:167156 )

• in the kidney cortex, beta-intercalated cells are replaced with alpha-intercalated cells unlike in wild-type mice

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:167156 )

N • mice exhibit normal compound action potentials