Phenotypes Associated with This Genotype

Genotype
MGI:4868729

• Allelic Composition: H2^g7/H2^g7; Tg(TcraAI4)1Dvs/0; Tg(TcrbAI4)1Dvs/0
• Genetic Background: B6.NOD-(D17Mit21-D17Mit10) Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to autoimmune diabetes ( J:167508 )

• Background Sensitivity: although negative selection of these transgenic thymocytes is stronger on the B6 than NOD background, there is earlier onset and greater penetrance of diabetes in females on the B6 background

• Background Sensitivity: compared with those on the NOD background, on the B6 background these TCR transgenic T cells have greater proliferative response to antigen presentation and display more potent killing of pancreatic islet cells