Phenotypes Associated with This Genotype

Genotype
MGI:4868435

• Allelic Composition: \Del(10Prmt2-Cstb)4Yah/\+; \Tc(HSA21)1TybEmcf/0
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H/HeH * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:167359 )

abnormal spatial learning ( J:167359 )

• slower to learn task in a Morris Maze test

• travelled further to find the hidden platform

abnormal spatial reference memory ( J:167359 )

• little retention of learning seen during probe trials in a Morris Maze test

decreased anxiety-related response ( J:167359 )

• less time spent in the periphery of an open field test

abnormal motor coordination/balance ( J:167359 )

impaired coordination ( J:167359 )

• perform poorly on a rotarod

• fall of a rotarod more rapidly and at slower speeds

• rotarod performance does not improve with practice

impaired limb coordination ( J:167359 )

• 25% more errors than controls on a notched bar test of hindlimb performance

abnormal social investigation ( J:167359 )

• investigation of a newly introduced mouse is normal

• no distinction made between mice after the later introduction of a second new mouse