Phenotypes Associated with This Genotype

Genotype
MGI:4868239

• Allelic Composition: Adrm1^{Gt(OST128063)Lex}/Adrm1^{Gt(OST128063)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased body weight in early life and higher body fat content in Adrm1^{Gt(OST128063)Lex}/Adrm1^{Gt(OST128063)Lex} mice

mortality/aging

postnatal lethality ( J:166694 )

reproductive system

abnormal oocyte morphology ( J:166694 )

♀ • ova are surrounded by a single layer of cell unlike in wild-type mice

decreased oocyte number ( J:166694 )

♀

azoospermia ( J:166694 )

♂

abnormal male germ cell apoptosis ( J:166694 )

♂

abnormal ovary morphology ( J:166694 )

♀ • mice exhibit vacuolated interstitial ovarian stroma compared with wild-type mice

absent corpus luteum ( J:166694 )

♀

abnormal ovarian follicle morphology ( J:166694 )

♀ • mice exhibit only a few secondary atretic and cystic follicles compared with wild-type mice

absent primordial ovarian follicles ( J:166694 )

♀

ovarian follicular cyst ( J:166694 )

♀

small seminiferous tubules ( J:166694 )

♂ • hypoplastic

female infertility ( J:166694 )

♀

male infertility ( J:166694 )

♂

immune system

immune system phenotype ( J:166694 )

N • mice exhibit normal B cell, NK cell, monocyte, and neutrophil numbers and stimulated thymocyte proliferation

enlarged thymus ( J:166694 )

thymus hyperplasia ( J:166694 )

• mice exhibit increased thymus cellularity compared with wild-type mice

• however, mice exhibit normal distribution of cells in the main developmental stages

increased CD4-positive, alpha-beta T cell number ( J:166694 )

• in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:166694 )

• in the peripheral blood

abnormal single-positive T cell number ( J:166694 )

• mice exhibit an increase in the CD4/CD8 T cell ratio in the spleen compared with wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:166694 )

N • mice exhibit normal testosterone and cortisol serum levels

increased circulating follicle stimulating hormone level ( J:166694 )

increased circulating growth hormone level ( J:166694 )

growth/size/body

growth/size/body region phenotype ( J:166694 )

N • mice exhibit normal birth weight at 6 to 8 weeks

ovarian follicular cyst ( J:166694 )

♀

decreased birth weight ( J:166694 )

adipose tissue

increased total body fat amount ( J:166694 )

abnormal abdominal fat pad morphology ( J:166694 )

• increased

behavior/neurological

abnormal behavior ( J:166694 )

• postnatal mice are less competitive for food compared with wild-type mice

endocrine/exocrine glands

enlarged thymus ( J:166694 )

thymus hyperplasia ( J:166694 )

• mice exhibit increased thymus cellularity compared with wild-type mice

• however, mice exhibit normal distribution of cells in the main developmental stages

abnormal ovary morphology ( J:166694 )

♀ • mice exhibit vacuolated interstitial ovarian stroma compared with wild-type mice

absent corpus luteum ( J:166694 )

♀

abnormal ovarian follicle morphology ( J:166694 )

♀ • mice exhibit only a few secondary atretic and cystic follicles compared with wild-type mice

absent primordial ovarian follicles ( J:166694 )

♀

ovarian follicular cyst ( J:166694 )

♀

small seminiferous tubules ( J:166694 )

♂ • hypoplastic

hematopoietic system

enlarged thymus ( J:166694 )

thymus hyperplasia ( J:166694 )

• mice exhibit increased thymus cellularity compared with wild-type mice

• however, mice exhibit normal distribution of cells in the main developmental stages

increased CD4-positive, alpha-beta T cell number ( J:166694 )

• in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:166694 )

• in the peripheral blood

abnormal single-positive T cell number ( J:166694 )

• mice exhibit an increase in the CD4/CD8 T cell ratio in the spleen compared with wild-type mice

cellular

abnormal oocyte morphology ( J:166694 )

♀ • ova are surrounded by a single layer of cell unlike in wild-type mice

decreased oocyte number ( J:166694 )

♀

azoospermia ( J:166694 )

♂

abnormal male germ cell apoptosis ( J:166694 )

♂