Phenotypes Associated with This Genotype

Genotype
MGI:4868225

• Allelic Composition: Rassf5^tm1Sblee/Rassf5^tm1Sblee
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rassf5^tm1Sblee/Rassf5^tm1Sblee mice are resistant to TNF-alpha-induced apoptosis

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:166871 )

• survive up to 12 hours after tail vein injection of TNF alpha and D-galactosamine whereas controls die within 7 hours

cellular

decreased fibroblast apoptosis ( J:166871 )

• mouse embryo fibroblasts are resistant to apoptosis induced by TNF alpha when compared to control MEFs

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:166871 )

• survive up to 12 hours after tail vein injection of TNF alpha and D-galactosamine whereas controls die within 7 hours