Phenotypes for Atoh7 Rest Tg(Six3-cre)69Frty MGI:4867681 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Atoh7^tm2Gan/Atoh7^tm2Gan Rest^tm1.1Whk/Rest^tm1.1Whk Tg(Six3-cre)69Frty/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm2Gan mutation (0 available); any Atoh7 mutation (9 available)
Rest^tm1.1Whk mutation (0 available); any Rest mutation (92 available)
Tg(Six3-cre)69Frty mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina morphology ( J:167071 )

• mis-patterning of the retina is more severe than in mutant mice wild-type for Atoh7

abnormal retina development ( J:167071 )

• few ganglion cells are detected in the nascent retinal ganglion layer at E13.5 despite many being generated in the neuroblast layer suggesting a defect in migration and maturation

• many dying cells are present in the retinal ganglion cell layer at E13.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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