Phenotypes Associated with This Genotype

Genotype
MGI:4867680

• Allelic Composition: Rest^tm1.1Whk/Rest^tm1.1Whk; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina progenitor cell morphology ( J:167071 )

• increase in the number of mitotic retinal progenitor cells compared to littermate controls

abnormal retina ganglion layer morphology ( J:167071 )

• many cell clumps protrude towards the retinal pigment epithelia

increased retina ganglion cell number ( J:167071 )

• at E14, E15.5 and P20

thick retina ganglion layer ( J:167071 )

• at P20

thick retina inner plexiform layer ( J:167071 )

• thicker at P20

nervous system

increased retina ganglion cell number ( J:167071 )

• at E14, E15.5 and P20